Xelpro 20 is used to manage various gastrointestinal conditions, ranging from acid-related dyspepsia to more severe issues like erosive esophagitis and ulcers.
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Esomeprazole is a medication used to treat various stomach and intestinal conditions, including peptic ulcers, esophagitis, gastroesophageal reflux disease (GERD), stress ulcers, and acidity caused by painkillers. It works by reducing the production of stomach acid.
This medication is available in various forms, including tablets, capsules, injections, and granules for oral suspension. When taking oral forms, it's recommended to take the medicine one hour before meals, and to take it at the same time each day to maintain a consistent level in the blood. It's important not to stop taking esomeprazole without consulting your doctor, as symptoms may reappear.
It's not recommended to use esomeprazole if you are allergic to it. Inform your doctor about any liver or kidney problems, or any other health conditions you may have.
Heartburn, Acid Related Dyspepsia, Peptic ulcer disease, Zollinger-Ellison syndrome, Gastroesophageal reflux disease (GERD), Helicobacter pylori infection, Erosive Esophagitis, Gouty arthritis, Duodenal and Gastric Ulcer.
Common side effects include headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth.
Esomeprazole, a proton pump inhibitor, works by inhibiting the H+/K+-ATPase in the gastric parietal cell, thereby suppressing gastric acid secretion. It is the S-isomer of omeprazole and the first single optical isomer of a proton pump inhibitor, offering improved acid control compared to racemic proton pump inhibitors.
After oral administration, esomeprazole is absorbed with peak plasma levels occurring around 1.5 hours. Increasing the dose leads to a proportional increase in peak plasma levels, with systemic bioavailability approximately 90% after repeated once-daily dosing. However, food intake decreases the absorption of esomeprazole, resulting in a 33-53% decrease in plasma levels when taken with food. Therefore, it is recommended to take esomeprazole at least one hour before meals.
Esomeprazole is extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, primarily CYP2C19 and to a lesser extent CYP3A4. The metabolites lack anti-secretory activity. Only a small fraction of the parent drug is excreted unchanged in the urine, with approximately 80% excreted as inactive metabolites in urine and feces combined.
In combination therapy with antimicrobials like clarithromycin and amoxicillin, esomeprazole's pharmacokinetic parameters may be altered, with increases in steady-state AUC and Cmax. However, these changes are not considered clinically significant.
Esomeprazole should be swallowed whole and taken one hour before a meal.
Xelpro may interfere with drugs metabolized by CYP2C19 and affect the absorption of drugs sensitive to gastric pH. It doesn't significantly interact with many common medications, but caution is needed with diazepam and drugs affected by gastric pH.
Esomeprazole is contraindicated in patients with known hypersensitivity to any component of the formulation or substituted Benzimidazoles.
Adequate studies in pregnant women are lacking, but animal studies showed no teratogenic effects. Breastfeeding should be discontinued if esomeprazole use is deemed essential.
Store at temperatures below 30°C, protect from light and moisture, and Keep it away from children and pets.
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