Xelpro Capsule | Esomeprazole 20mg | 10pcs | Price | ePharma
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Xelpro 20mg Capsule 10pcs

Generic: Esomeprazole

Type: Tablet

Pack Size: 10 Pcs

Xelpro 20 is used to manage various gastrointestinal conditions, ranging from acid-related dyspepsia to more severe issues like erosive esophagitis and ulcers.


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Discount Price: ৳ 75.2
MRP: ৳ 80 6% Off

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✅ Description:

Esomeprazole is a medication used to treat various stomach and intestinal conditions, including peptic ulcers, esophagitis, gastroesophageal reflux disease (GERD), stress ulcers, and acidity caused by painkillers. It works by reducing the production of stomach acid.

This medication is available in various forms, including tablets, capsules, injections, and granules for oral suspension. When taking oral forms, it's recommended to take the medicine one hour before meals, and to take it at the same time each day to maintain a consistent level in the blood. It's important not to stop taking esomeprazole without consulting your doctor, as symptoms may reappear.

It's not recommended to use esomeprazole if you are allergic to it. Inform your doctor about any liver or kidney problems, or any other health conditions you may have. 

Safety Advices


Alcohol

Pregnancy

Breastfeeding

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✔️ Uses:

Heartburn, Acid Related Dyspepsia, Peptic ulcer disease, Zollinger-Ellison syndrome, Gastroesophageal reflux disease (GERD), Helicobacter pylori infection, Erosive Esophagitis, Gouty arthritis, Duodenal and Gastric Ulcer.

✔️ How does
✔️ Side Effects

Common side effects include headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth.

✔️ Quick Suggestions:
  • Take Esomeprazole as instructed by your doctor. 
    Do not break, crush, or chew the tablet/capsule.
  • Take Esomeprazole for the recommended duration.
  • Avoid taking more or less than the prescribed dose.
  • Avoid spicy and fatty foods, alcohol, and caffeinated drinks or beverages (such as coffee, tea, and cola) while taking this medicine.
✔️ Indications:
✔️ Pharmacology

Esomeprazole, a proton pump inhibitor, works by inhibiting the H+/K+-ATPase in the gastric parietal cell, thereby suppressing gastric acid secretion. It is the S-isomer of omeprazole and the first single optical isomer of a proton pump inhibitor, offering improved acid control compared to racemic proton pump inhibitors.

After oral administration, esomeprazole is absorbed with peak plasma levels occurring around 1.5 hours. Increasing the dose leads to a proportional increase in peak plasma levels, with systemic bioavailability approximately 90% after repeated once-daily dosing. However, food intake decreases the absorption of esomeprazole, resulting in a 33-53% decrease in plasma levels when taken with food. Therefore, it is recommended to take esomeprazole at least one hour before meals.

Esomeprazole is extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, primarily CYP2C19 and to a lesser extent CYP3A4. The metabolites lack anti-secretory activity. Only a small fraction of the parent drug is excreted unchanged in the urine, with approximately 80% excreted as inactive metabolites in urine and feces combined.

In combination therapy with antimicrobials like clarithromycin and amoxicillin, esomeprazole's pharmacokinetic parameters may be altered, with increases in steady-state AUC and Cmax. However, these changes are not considered clinically significant.

✔️ Dosage & Administration:
  • To heal erosive esophagitis, Xelpro is typically taken orally at either 20 mg or 40 mg once daily for 4 to 8 weeks. If healing hasn't occurred after this period, an additional 4 to 8 weeks of treatment may be considered. For maintenance therapy to sustain healing, a dose of 20 mg once daily is recommended, although clinical studies did not extend beyond 6 months.
  • For symptomatic gastroesophageal reflux disease (GERD), a dosage of 20 mg once daily is typically prescribed for 4 weeks. If symptoms persist after this period, an additional 4 weeks of treatment may be warranted.
  • Helicobacter pylori eradication typically involves triple therapy, consisting of esomeprazole 40 mg once daily, amoxicillin 1000 mg twice daily, and clarithromycin 500 mg twice daily, all taken for 10 days.
  • For Zollinger-Ellison Syndrome, the recommended dosage of Xelpro ranges from 20 mg to 80 mg once daily, with individual adjustments as needed based on clinical response.
  • In cases of acid-related dyspepsia, Xelpro is usually taken at a dose of 20 mg to 40 mg once daily for 2 to 4 weeks, depending on the patient's response.
  • For duodenal ulcers, a dosage of 20 mg once daily for 2 to 4 weeks is typically prescribed, while gastric ulcers may require a higher dose of 20 mg to 40 mg once daily for a duration of 4 to 8 weeks.

Esomeprazole should be swallowed whole and taken one hour before a meal.

✔️ Interaction

Xelpro may interfere with drugs metabolized by CYP2C19 and affect the absorption of drugs sensitive to gastric pH. It doesn't significantly interact with many common medications, but caution is needed with diazepam and drugs affected by gastric pH.

✔️ Contraindications:

Esomeprazole is contraindicated in patients with known hypersensitivity to any component of the formulation or substituted Benzimidazoles.

✔️ Pregnancy & Lactation

Adequate studies in pregnant women are lacking, but animal studies showed no teratogenic effects. Breastfeeding should be discontinued if esomeprazole use is deemed essential.

✔️ Precautions & Warnings
  • Always check the date of expiry before taking this medicine.
  • Throw away the unused medicine safely after it has expired.
  • Safety and effectiveness haven't been established.
  • No significant differences were observed between elderly and younger patients, but caution is advised.
  • No dosage adjustment is needed for mild to moderate hepatic insufficiency, but dosage should not exceed 20 mg once daily in severe cases.
  • Pharmacokinetics aren't expected to be altered in renal impairment.
✔️ Storage Conditions:

Store at temperatures below 30°C, protect from light and moisture, and Keep it away from children and pets.

Frequently Asked Questions (FAQ)

A: Usually, Esomeprazole is taken once a day, first thing in the morning. If taken twice a day, one dose should be in the morning and one in the evening, at least 1 hour before a meal.

A: No habit-forming tendencies were reported for Esomeprazole.

A: Interaction with alcohol is unknown. Consult your doctor before consumption.

A: Esomeprazole may remain in your body for an average duration of 9 hours.

A: It's advisable to avoid alcohol with Esomeprazole as it may increase acid production and worsen symptoms.

A: Long-term use of Esomeprazole may lead to low magnesium levels, bone fractures, stomach infections, and vitamin B12 deficiency, among other potential side effects.

A: Yes, Esomeprazole can be taken with ranitidine, but only if prescribed by a doctor.

A: Yes, Esomeprazole is generally safe when taken as directed by a doctor.

A: You may start to feel better within 1 hour after taking oral forms of Esomeprazole, while the effect is immediate after intravenous injection.

A: Abruptly stopping Esomeprazole, especially after long-term use, may worsen symptoms. Discuss any dose changes with your doctor.

A: Esomeprazole is usually prescribed for short-term use, but long-term use may be necessary for certain conditions like peptic ulcer disease and Zollinger-Ellison syndrome (ZES), under a doctor's supervision.

A: Yes, Esomeprazole can be safely taken with domperidone, often prescribed together for conditions like reflux esophagitis.

A: Yes, antacids can be taken with Esomeprazole, preferably 2 hours before or after Esomeprazole.

A: Weight gain is rare with Esomeprazole, but lifestyle changes like diet and exercise can help manage it if it occurs.
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Check our pricing section for Xelpro 20mg Capsule 10pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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